Trevigen, Inc. Opens Organoid Resource Lab

Trevigen, Inc. is pleased to announce the opening of the Organoid Resource Laboratory (ORL) at its Gaithersburg, Maryland location. The purpose of the ORL is to provide the research community with the matrices, reagents, growth factors, organoid progenitor cells, protocols and technical support to promote the establishment of organoid culture.

The Need:

Recent estimates on the cost to bring a prescription drug to market range from $2.5 to $5.0 billion. A major contributing factor to the expense is the prolonged testing time required to fail a drug. Prolonged testing can occur when drugs are screened on classical 2-D cell cultures grown on glass or plastic labware. The 2-D environment creates changes in cell morphology and function so that the cell culture no longer represents the tissue of origin in the body. A consequence is that the reaction of the 2-D cell culture to a candidate drug can be misleading, and the experimental drug undergoes further expensive animal testing instead of being dropped. The inadequacy of 2-D culture models extends beyond drug screening and can adversely affect costs and outcomes in cancer research, genetic toxicology and regenerative medicine.

The Alternative:

Researchers have devised means to propagate 3-D cultures which most closely mimic the physiological response patterns of the tissue of origin. The ultimate form of 3-D culture is the organoid which is cultured from progenitor stem cells taken from a fresh target organ. The cells never come in direct contact with glass or plastic labware and under stringent, prescribed conditions, can be cultured to become mini-organs that closely resemble the original source organ, and exhibit the proper physiological response patterns.

The Challenges:

Establishment of organoid culture can take 6 to 9 months. Even the most experienced labs have multiple failures when establishing organoid cultures from fresh tissue or induced pluripotent stem cells. Protocols are both rigorous and complex and the organoids produced must be qualified to show differentiation into appropriate organ structures.

Organoid qualified extracellular matrix, growth media, growth factors and harvesting solutions are required in order to create successful organoid cultures from progenitor cells. In addition, labs are faced with limited passage numbers requiring continuous generation of new organoid cultures.

The Solution:

Trevigen has been providing Cultrex® brand organoid qualified extracellular matrix to the research community for the last several years. Recently, Trevigen has also developed and makes available growth factors, harvesting solution, and has begun to develop human and mouse organoid progenitor cells for important target organs. Trevigen now offers these highly qualified organoid culture products along with protocols for use and technical services support, to assist the adoption of organoid culture by both new and experienced labs alike.

About Trevigen:

Trevigen is a long time provider of products qualified for 3-D culture, sold under the Cultrex® brand. Trevigen is a fully integrated company having product development laboratories and a production facility in Gaithersburg, MD. Organoids are now routinely cultured and qualified in the Organoid Resource Laboratory.

To learn more about the products and support for organoid culture available from our Organoid Resource Lab, visit
https://www.trevigen.com/product/7/58/0/Organoid_Culture/ or contact us at info@trevigen.com.