The Cultrex® 10X Spheroid Formation ECM and Plate provide a powerful tool for modeling tumor growth in vitro. Tumor cell aggregates, or spheroids, are more representative of tumors in vivo, and they exhibit several physiological traits including similar morphology, formation of cell-cell bonds, decreased proliferation rates, increased cell survival, tumor dormancy, and a hypoxic core. Applying this model to a 3D culture cell assay provides a more physiological approach for objectively studying tumor growth.
The Cultrex® 10X Spheroid Formation ECM is a proprietary mixture of extracellular matrix proteins derived from murine EHS sarcoma and optimized for spheroid formation. The diluted ECM is a fluid in culture that promotes cell-cell adhesion when cells are cultured in the Cultrex® 3D Culture Qualified 96 Well Spheroid Formation Plate.