Anti-8-oxo-dG Monoclonal Antibody

This mouse monoclonal antibody (clone 15A3) specifically binds to 8-hydroxy-2′- deoxyguanosine within DNA. It can be used to detect oxidative damage by ELISA and immunocytochemistry.

Available Size(s): 50 μl Catalog Number: 4354-MC-050 Category:

Description

ANTIBODY CONCENTRATION
Provided at 0.5 mg/ml in 1X PBS containing 0.1% sodium azide and 50% glycerol.
This mouse monoclonal antibody is an IgG2b purified from mouse ascites.
IMMUNOGEN
8-oxo-dG-conjugated-KLH
SPECIFICITY
This  antibody specifically binds to 8-hydroxy-2′- deoxyguanosine within DNA.
STORAGE
Freeze in working aliquots at -20°C in a manual defrost freezer.
APPLICATIONS
ELISA and Immunocytochemistry

Protocol(s)

protocol_4354-MC-050

Material Safety Data Sheet(s)

msds_4354-MC-050 Anti- 8-oxo-dG Antibody

Mitochondrial Oxidative Stress-Induced Epigenetic Modif ications in Pancreatic Epithelial Cells
Mishra, P.K., Raghuram, G.V., Jain, D., Jain, S.K., Khare, N.K. and Pathak, N.
International Journal of Toxicology, Mar 2014; 33: 116 – 129
http://ijt.sagepub.com/cgi/content/abstract/33/2/116

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
Tongde Wu, Fei Zhao, Beixue Gao, Can Tan, Naoko Yagishita, Toshihiro Nakajima, Pak K. Wong, Eli Chapman, Deyu Fang, and Donna D. Zhang
Genes & Dev., Apr 2014; 28: 708 – 722
http://genesdev.cshlp.org/cgi/content/abstract/28/7/708

Diabetes-Induced Oxidative DNA Damage Alters p53-p21CIP1/Waf1 Signaling in the Rat Testis
Kilarkaje, N. and Al-Bader, M.M.,
Reproductive Sciences, May 2014; 10.1177/1933719114533729.
http://rsx.sagepub.com/cgi/content/abstract/1933719114533729v1

Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice
Arlin B. Rogers, Hadley J. Hartwell, Keiko Y. Petrosky, James G. Fox, Nelson D. Horseman, and Arlin B. Rogers
PNAS, Aug 2014; 111: 11455 – 11460.
http://www.pnas.org/cgi/content/abstract/111/31/11455

“Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma”
Xiaoqi Xie, Ju Yong Koh, Sandy Price, Eileen White, and Janice M. Mehnert
Cancer Discovery, Apr 2015; 5: 410 – 423.
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/5/4/410

“Nrf2-Dependent Suppression of Azoxymethane/Dextran Sulfate Sodium–Induced Colon Carcinogenesis by the Cinnamon-Derived Dietary Factor Cinnamaldehyde”
“Min Long, Shasha Tao, Montserrat Rojo de la Vega, Tao Jiang, Qing Wen, Sophia L.Park, Donna D. Zhang, and Georg T. Wondrak”
Cancer Prevention Research, May 2015; 8: 444 – 454.
http://cancerpreventionresearch.aacrjournals.org/cgi/content/abstract/8/5/444

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway

Nicolas Paquet, Mark N. Adams, Vincent Leong, Nicholas W. Ashton, Christine Touma, Roland Gamsjaeger, Liza Cubeddu, Sam Beard, Joshua T. Burgess, Emma Bolderson, Ken J. O’Byrne, and Derek J. Richard
Nucleic Acids Res., Oct 2015; 43: 8817 – 8829.
http://nar.oxfordjournals.org/cgi/content/abstract/43/18/8817

An Essential Role of NRF2 in Diabetic Wound Healing
Min Long, Montserrat Rojo de la Vega, Qing Wen, Manish Bharara, Tao Jiang, Rui Zhang, Shiwen Zhou, Pak K. Wong, Georg T. Wondrak, Hongting Zheng, and Donna D. Zhang
Diabetes, Mar 2016; 65: 780 – 793
http://diabetes.diabetesjournals.org/cgi/content/abstract/65/3/780

“Mitochondrial targeting of XJB-5-131 attenuates or improves
pathophysiology in HdhQ150 animals with well-developed disease
phenotypes”

“Aris Polyzos, Amy Holt, Christopher Brown, Celica Cosme, Peter Wipf, Alex Gomez-Marin, Maríadel R.
Castro, Sylvette Ayala-Peña, and Cynthia T. McMurray”
Hum. Mol. Genet., Mar 2016; 10.1093/hmg/ddw051
http://hmg.oxfordjournals.org/cgi/content/abstract/ddw051v2

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
Vinodkumar B. Pillai, Samik Bindu, Will Sharp, Yong Hu Fang, Gene Kim, Madhu Gupta, Sadhana Samant, and Mahesh P. Gupta
Am J Physiol Heart Circ Physiol, Apr 2016; 310: H962 – H972.
http://ajpheart.physiology.org/cgi/content/abstract/310/8/H962

“L-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1”
Irene Llorente-Folch, Carlos B. Rueda, Irene Pérez-Liébana, Jorgina Satrústegui, and Beatriz Pardo
J. Neurosci., Apr 2016; 36: 4443 – 4456.
http://www.jneurosci.org/cgi/content/abstract/36/16/4443

“Endothelin Receptor A Antagonism Prevents Damage to Glycogen-Rich Placental Cells Following Uterine Ischemia–Reperfusion in the Rat”
Larry G. Thaete, Saira Khan, and Mark G. Neerhof
Reproductive Sciences, Apr 2016; 10.1177/1933719116645190.
http://rsx.sagepub.com/cgi/content/abstract/1933719116645190v1

Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury
Tsung-Hsun Hsieh, Henry Hing Cheong Lee, Mustafa Qadir Hameed, Alvaro Pascual-Leone, Takao K. Hensch, and Alexander Rotenberg
Cereb Cortex, Nov 2016; 10.1093/cercor/bhw318.
http://cercor.oxfordjournals.org/cgi/content/abstract/bhw318v1

“Endothelin Receptor A Antagonism Prevents Damage to Glycogen-Rich
Placental Cells Following Uterine Ischemia–Reperfusion in the Rat”

Larry G. Thaete, Saira Khan, and Mark G. Neerhof
Reproductive Sciences, Nov 2016; 23: 1518 – 1525.
http://rsx.sagepub.com/cgi/content/abstract/23/11/1518

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

Shasha Tao, Shue Wang, Seyed Javad Moghaddam, Aikseng Ooi, Eli Chapman, Pak K. Wong, and Donna D. Zhang
Cancer Res., Dec 2014; 74: 7430 – 7441.
http://cancerres.aacrjournals.org/cgi/content/abstract/74/24/7430

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
Ismail Abdou, Guy G. Poirier, Michael J. Hendzel, and Michael Weinfeld
Nucleic Acids Res., Jan 2015; 43: 875 – 892
http://nar.oxfordjournals.org/cgi/content/abstract/43/2/875