Etoposide

$65.00

Available Size(s): 100 μl Catalog Number: 4684-096-06 Category:

Description

Although the entire signaling pathways mediating etoposide-induced apoptosis are not clear, double-stranded and single-stranded DNA breaks induced by etoposide have been shown to activate the p53 activity by phosphorylation, resulting in an up-regulation of the pro-apoptotic protein Bax. The translocation of Bax to the mitochondria induces the MPT, the event that releases cytochrome c and culminates in the death of the cells. Etoposide also blocks the cell cycle in S-phase and G2-phase; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.

Physical State: Etoposide is provided in DMSO. The final reagent concentration is 10 mM.

 

Protocol(s)

protocol_4684-096-06

 

Material Safety Data Sheet(s)

msds_4684-096-06 10 mM Etoposide