gamma-H2AX Kit and Antibody

The visualization of DNA damage response proteins enables the indirect measurement of DNA damage. Cellular exposure to ionizing radiation or DNA-damaging chemotherapeutic agents results in DNA damage in the form of double-strands breaks (DSBs). The fast and abundant phosphorylation of H2AX at Ser 139 (gamma-H2AX) correlates well with each DSB making it a sensitive marker for the level of DNA damage and the subsequent DNA repair of the lesion. A gamma-H2AX kit and antibody allows the assessment of DNA damage and DNA repair for ELISA based assays, immunohistochemistry or flow cytometry. In the detection of genomic damage, gamma-H2AX is especially important in research involving cancer treatment and therapy, and environmental biomonitoring.

Trevigen’s gamma-H2AX Pharmacodynamic assay is the first commercially available ELISA kit to quantify phosphorylated levels of gamma-H2AX in PBMCs, cultured cells and tissue biopsies. Also offered is the DNA damage detecting antibody for double-strand breaks, Anti-Phosphorylated Histone H2AX Affinity Purified Polyclonal.

Contract Services are also offered for the gamma-H2AX Kit.

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