TACS•XL® In Situ Apoptosis Detection

The TACS•XL® Kit is based on incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that are formed during apoptosis. The incorporation of BrdU by TdT is more efficient than either biotinylated or digoxigenin labeled nucleotides used in other terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-based assays. The detection system utilizes a biotin conjugated anti-BrdU antibody and streptavidin-horseradish peroxidase. The combination of antibody specificity with the signal enhancing properties of biotin streptavidin results in precise cellular labeling and the highest signal-to-noise ratio observed in competitive testing.

Three general kit formats are available: TACS•XL® DAB, TACS•XL® Blue Label, and TACS•XL® Basic as well as a  DermaTACS™ tailored for detection of apoptosis in skin or epithelium samples. The TACS•XL® DAB Kit is supplied with DAB and Methyl Green counterstain, and the TACS•XL® Blue Label Kit is provided with TACS Blue Label™ and Nuclear Fast Red counterstain. These complete kits provide all the reagents required for labeling including two permeabilization reagents, labeling and detection reagents, stop buffers, counterstain and TACS-Nuclease™ reagents for generating positive controls with your own samples. The TACS•XL® Basic Kit provides the reagents necessary for routine labeling, and is ideal for researchers whose labs are equipped for standard immunohistochemical procedures involving horseradish-peroxidase.

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  • TACS·XL® Kits

    TACS·XL® Kits (3)

    The TACS•XL® Kits use an biotinylated antibody to detect the incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that are formed during apoptosis.  The combination of antibody specificity with the signal enhancing properties of biotin streptavidin results in precise cellular labeling and the highest signal-to-noise ratio observed in competitive testing.

    Three general kit formats are available: TACS•XL® DAB, TACS•XL® Blue Label, and TACS•XL® Basic as well as a  DermaTACS™ tailored for detection of apoptosis in skin or epithelium sample.

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    • TACS•XL® Modules

      TACS•XL® Modules (5)

      A variety of modules can be purchased to complement the TACS•XL® kits to better serve individual needs.
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